Article
MAGEA10 gene expression in non-small cell lung cancer and A549 cells, and the affinity of epitopes with the complex of HLA-A(∗)0201 alleles.
Cellular immunology - 1 Sept 2015
Wang Likui, Xu Yuefang, Luo Cheng, Sun Jian, Zhang Jinlu, Lee Ming-Wei, Bai Aiping, Chen Guanhua, Frenz Christopher M, Li Zhengguo, Huang Wenlin
Abstract excerpt
MAGEA10, a cancer/testis antigens expressed in tumors but not in normal tissues with the exception of testis and placenta, represents an attractive target for cancer immunotherapy. However, suppressive cytoenvironment and requirement of specific HLA-alleles presentation frequently led to immunotherapy failure. In this study MAGEA10 was scarcely expressed in cancer patients, but enhanced by viili polysaccharides,...
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