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Article

The integrated landscape of driver genomic alterations in glioblastoma.

Nature genetics - 1 Oct 2013

Frattini Veronique, Trifonov Vladimir, Chan Joseph Minhow, Castano Angelica, Lia Marie, Abate Francesco, Keir Stephen T, Ji Alan X, Zoppoli Pietro, Niola Francesco, Danussi Carla, Dolgalev Igor, Porrati Paola, Pellegatta Serena, Heguy Adriana, Gupta Gaurav, Pisapia David J, Canoll Peter, Bruce Jeffrey N, McLendon Roger E, Yan Hai, Aldape Ken, Finocchiaro Gaetano, Mikkelsen Tom, Privé Gilbert G, Bigner Darell D, Lasorella Anna, Rabadan Raul, Iavarone Antonio

Abstract excerpt

Glioblastoma is one of the most challenging forms of cancer to treat. Here we describe a computational platform that integrates the analysis of copy number variations and somatic mutations and unravels the landscape of in-frame gene fusions in glioblastoma. We found mutations with loss of heterozygosity in LZTR1, encoding an adaptor of CUL3-containing E3 ligase complexes. Mutations and deletions disrupt LZTR1...

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Source

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Identifiers

PMID: 23917401
DOI: 10.1038/ng.2734
PMCID: PMC3799953

Genes

EGFR
LZTR1
CTNND2
CUL3
STAT3

Provenance

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