Article
EGFR variant heterogeneity in glioblastoma resolved through single-nucleus sequencing.
Cancer discovery - 1 Aug 2014
Francis Joshua M, Zhang Cheng-Zhong, Maire Cecile L, Jung Joonil, Manzo Veronica E, Adalsteinsson Viktor A, Homer Heather, Haidar Sam, Blumenstiel Brendan, Pedamallu Chandra Sekhar, Ligon Azra H, Love J Christopher, Meyerson Matthew, Ligon Keith L
Abstract excerpt
UNLABELLED: Glioblastomas (GBM) with EGFR amplification represent approximately 50% of newly diagnosed cases, and recent studies have revealed frequent coexistence of multiple EGFR aberrations within the same tumor, which has implications for mutation cooperation and treatment resistance. However, bulk tumor sequencing studies cannot resolve the patterns of how the multiple EGFR aberrations coexist with other...
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