Article
Light causes phosphorylation of nonactivated visual pigments in intact mouse rod photoreceptor cells.
The Journal of biological chemistry - 16 Dec 2005
Shi Guang W, Chen Jiayan, Concepcion Francis, Motamedchaboki Khatereh, Marjoram Paul, Langen Ralf, Chen Jeannie
Abstract excerpt
Phosphorylation of G-protein-coupled receptors (GPCRs) is a required step in signal deactivation. Rhodopsin, a prototypical GPCR, exhibits high gain phosphorylation in vitro whereby a hundred-fold molar excess of phosphates are incorporated into the rhodopsin pool per molecule of activated rhodopsin. The extent by which high gain phosphorylation occurs in the intact mammalian photoreceptor cell, and the molecular...
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