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Article

Evidence that active demethylation mechanisms maintain the genome of carcinoma in situ cells hypomethylated in the adult testis

28 Nov 2013

Abstract excerpt

BACKGROUND: Developmental arrest of fetal germ cells may lead to neoplastic transformation and formation of germ cell tumours via carcinoma in situ (CIS) cells. Normal fetal germ cell development requires complete erasure and re-establishment of DNA methylation. In contrast to normal spermatogonia, the genome of CIS cells remains unmethylated in the adult testis. We here investigated the possible active and...

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Share to Epigenetics and DNA Methylation
Share to Genomics and Chromatin Dynamics
Share to Testicular diseases and treatments

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Identifiers

PMID: 24292451
DOI: 10.1038/bjc.2013.727

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