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Active Demethylation of Paternal Genome in Mammalian Zygotes

1 Jan 2009

Abstract excerpt

Epigenetic reprogramming in early preimplantation embryos, that refers to erasing and remodeling epigenetic marks such as DNA methylation, is essential for differentiation and development. In many species, paternal genome is subjected to genome-wide active demethylation before the DNA replication commences, while maternal genome maintains its methylation status until being demethylated passively during the...

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PMID: 19721335
DOI: 10.1262/jrd.20234

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