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Article

Carcinoma in situ testis displays permissive chromatin modifications similar to immature foetal germ cells

7 Sept 2010

Abstract excerpt

BACKGROUND: The majority of testicular germ cell cancers develop through a pre-invasive carcinoma in situ (CIS) stage. The CIS cell is a neoplastic counterpart of foetal germ cells. During their development, foetal germ cells undergo extensive and essential epigenetic modifications, but little is known about epigenetic patterns in CIS cells. METHODS: Immunohistochemistry was used to investigate epigenetic...

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PMID: 20823885
DOI: 10.1038/sj.bjc.6605880

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