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Article

The testicular germ cell tumour genome.

APMIS : acta pathologica, microbiologica, et immunologica Scandinavica - 1 Jan 2003

Skotheim Rolf I, Lothe Ragnhild A

Abstract excerpt

Human testicular germ cell tumour (TGCT) of adolescents and young adults develop from precursor lesions called carcinoma in situ (CIS), which is believed to originate from diploid primordial germ cells during foetal life. CIS is initiated by an aneuploidisation event accompanied by extensive chromosome instability. The further transformation of CIS into invasive TGCT (seminomas and nonseminomas) is associated...

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Identifiers

PMID: 12752254
DOI: 10.1034/j.1600-0463.2003.11101181.x

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