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Article

Global DNA methylation in fetal human germ cells and germ cell tumours: association with differentiation and cisplatin resistance

4 May 2010

Abstract excerpt

Differences in the global methylation pattern, ie hyper- as well as hypo-methylation, are observed in cancers including germ cell tumours (GCTs). Related to their precursor cells, GCT methylation status differs according to histology. We investigated the methylation pattern of normal fetal, infantile, and adult germ cells (n = 103) and GCTs (n = 251) by immunohistochemical staining for 5-(m)cytidine. The global...

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PMID: 20593487
DOI: 10.1002/path.2725

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