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Article

Structural basis of the autophagy-related LC3/Atg13 LIR complex: recognition and interaction mechanism.

Structure (London, England : 1993) - 7 Jan 2014

Suzuki Hironori, Tabata Keisuke, Morita Eiji, Kawasaki Masato, Kato Ryuichi, Dobson Renwick C J, Yoshimori Tamotsu, Wakatsuki Soichi

Abstract excerpt

Autophagy is a bulk degradation pathway that removes cytosolic materials to maintain cellular homeostasis. The autophagy-related gene 13 (Atg13) and microtubule associate protein 1 light chain 3 (LC3) proteins are required for autophagosome formation. We demonstrate that each of the human LC3 isoforms (LC3A, LC3B, and LC3C) interacts with Atg13 via the LC3 interacting region (LIR) of Atg13. Using X-ray...

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Identifiers

PMID: 24290141
DOI: 10.1016/j.str.2013.09.023

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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