Article
Expression of a ULK1/2 binding-deficient ATG13 variant can partially restore autophagic activity in ATG13-deficient cells.
Autophagy - 1 Jan 2015
Hieke Nora, Löffler Antje S, Kaizuka Takeshi, Berleth Niklas, Böhler Philip, Drießen Stefan, Stuhldreier Fabian, Friesen Olena, Assani Kaivon, Schmitz Katharina, Peter Christoph, Diedrich Britta, Dengjel Jörn, Holland Petter, Simonsen Anne, Wesselborg Sebastian, Mizushima Noboru, Stork Björn
Abstract excerpt
Autophagy describes an intracellular process responsible for the lysosome-dependent degradation of cytosolic components. The ULK1/2 complex comprising the kinase ULK1/2 and the accessory proteins ATG13, RB1CC1, and ATG101 has been identified as a central player in the autophagy network, and it represents the main entry point for autophagy-regulating kinases such as MTOR and AMPK. It is generally accepted that the...
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