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Article

Binding of the Atg1/ULK1 kinase to the ubiquitin-like protein Atg8 regulates autophagy.

The EMBO journal - 12 Sept 2012

Kraft Claudine, Kijanska Monika, Kalie Eyal, Siergiejuk Edyta, Lee Sung Sik, Semplicio Giuseppe, Stoffel Ingrid, Brezovich Andrea, Verma Mayanka, Hansmann Isabella, Ammerer Gustav, Hofmann Kay, Tooze Sharon, Peter Matthias

Abstract excerpt

Autophagy is an intracellular trafficking pathway sequestering cytoplasm and delivering excess and damaged cargo to the vacuole for degradation. The Atg1/ULK1 kinase is an essential component of the core autophagy machinery possibly activated by binding to Atg13 upon starvation. Indeed, we found that Atg13 directly binds Atg1, and specific Atg13 mutations abolishing this interaction interfere with Atg1 function...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 22885598
DOI: 10.1038/emboj.2012.225
PMCID: PMC3442273

Genes

ULK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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