Article
Homotypic vacuole fusion in yeast requires organelle acidification and not the V-ATPase membrane domain.
Developmental cell - 25 Nov 2013
Coonrod Emily M, Graham Laurie A, Carpp Lindsay N, Carr Tom M, Stirrat Laura, Bowers Katherine, Bryant Nia J, Stevens Tom H
Abstract excerpt
Studies of homotypic vacuole-vacuole fusion in the yeast Saccharomyces cerevisiae have been instrumental in determining the cellular machinery required for eukaryotic membrane fusion and have implicated the vacuolar H(+)-ATPase (V-ATPase). The V-ATPase is a multisubunit, rotary proton pump whose precise role in homotypic fusion is controversial. Models formulated from in vitro studies suggest that it is the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.