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Article

The vacuolar kinase Yck3 maintains organelle fragmentation by regulating the HOPS tethering complex.

The Journal of cell biology - 31 Jan 2005

LaGrassa Tracy J, Ungermann Christian

Abstract excerpt

The regulation of cellular membrane flux is poorly understood. Yeast respond to hypertonic stress by fragmentation of the normally large, low copy vacuole. We used this phenomenon as the basis for an in vivo screen to identify regulators of vacuole membrane dynamics. We report here that maintenance of the fragmented phenotype requires the vacuolar casein kinase I Yck3: when Yck3 is absent, salt-stressed vacuoles...

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Identifiers

PMID: 15684030
DOI: 10.1083/jcb.200407141
PMCID: PMC2171739

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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