Article
Phenotypic switching induced by damaged matrix is associated with DNA methyltransferase 3A (DNMT3A) activity and nuclear localization in smooth muscle cells (SMC).
PloS one - 1 Jan 2013
Jiang Jia-Xin, Aitken Karen J, Sotiropoulos Chris, Sotiropolous Chris, Kirwan Tyler, Panchal Trupti, Zhang Nicole, Pu Shuye, Wodak Shoshana, Tolg Cornelia, Bägli Darius J
Abstract excerpt
Extracellular matrix changes are often crucial inciting events for fibroproliferative disease. Epigenetic changes, specifically DNA methylation, are critical factors underlying differentiated phenotypes. We examined the dependency of matrix-induced fibroproliferation and SMC phenotype on DNA methyltransferases. The cooperativity of matrix with growth factors, cell density and hypoxia was also examined. Primary...
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