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Article

Is the gene-environment interaction paradigm relevant to genome-wide studies? The case of education and body mass index.

Demography - 1 Feb 2014

Boardman Jason D, Domingue Benjamin W, Blalock Casey L, Haberstick Brett C, Harris Kathleen Mullan, McQueen Matthew B

Abstract excerpt

This study uses data from the Framingham Heart Study to examine the relevance of the gene-environment interaction paradigm for genome-wide association studies (GWAS). We use completed college education as our environmental measure and estimate the interactive effect of genotype and education on body mass index (BMI) using 260,402 single-nucleotide polymorphisms (SNPs). Our results highlight the sensitivity of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24281739
DOI: 10.1007/s13524-013-0259-4
PMCID: PMC4035460

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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