Article
A perspective on interaction effects in genetic association studies.
Genetic epidemiology - 1 Dec 2016
Aschard Hugues
Abstract excerpt
The identification of gene-gene and gene-environment interaction in human traits and diseases is an active area of research that generates high expectation, and most often lead to high disappointment. This is partly explained by a misunderstanding of the inherent characteristics of standard regression-based interaction analyses. Here, I revisit and untangle major theoretical aspects of interaction tests in the...
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