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Article

Uncovering buffered pleiotropy: a genome-scale screen for mel-28 genetic interactors in Caenorhabditis elegans.

G3 (Bethesda, Md.) - 10 Jan 2014

Fernandez Anita G, Mis Emily K, Lai Allison, Mauro Michael, Quental Angela, Bock Carly, Piano Fabio

Abstract excerpt

mel-28 (maternal-effect-lethal-28) encodes a conserved protein required for nuclear envelope function and chromosome segregation in Caenorhabditis elegans. Because mel-28 is a strict maternal-effect lethal gene, its function is required in the early embryo but appears to be dispensable for larval development. We wanted to test the idea that mel-28 has postembryonic roles that are buffered by the contributions of...

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PMID: 24281427
DOI: 10.1534/g3.113.008532
PMCID: PMC3887534

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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