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Article

The identification of FANCD2 DNA binding domains reveals nuclear localization sequences.

Nucleic acids research - 21 Aug 2017

Niraj Joshi, Caron Marie-Christine, Drapeau Karine, Bérubé Stéphanie, Guitton-Sert Laure, Coulombe Yan, Couturier Anthony M, Masson Jean-Yves

Abstract excerpt

Fanconi anemia (FA) is a recessive genetic disorder characterized by congenital abnormalities, progressive bone-marrow failure, and cancer susceptibility. The FA pathway consists of at least 21 FANC genes (FANCA-FANCV), and the encoded protein products interact in a common cellular pathway to gain resistance against DNA interstrand crosslinks. After DNA damage, FANCD2 is monoubiquitinated and accumulates on...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 28666371
DOI: 10.1093/nar/gkx543
PMCID: PMC5737651

Genes

FANCD2
FANCA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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