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Article

Involvement of TGFβ-induced phosphorylation of the PTEN C-terminus on TGFβ-induced acquisition of malignant phenotypes in lung cancer cells.

PloS one - 1 Jan 2013

Aoyama Daisuke, Hashimoto Naozumi, Sakamoto Koji, Kohnoh Takashi, Kusunose Masaaki, Kimura Motohiro, Ogata Ryo, Imaizumi Kazuyoshi, Kawabe Tsutomu, Hasegawa Yoshinori

Abstract excerpt

Transforming growth factor β (TGFβ) derived from the tumor microenvironment induces malignant phenotypes such as epithelial-mesenchymal transition (EMT) and aberrant cell motility in lung cancers. TGFβ-induced translocation of β-catenin from E-cadherin complexes into the cytoplasm is involved in the transcription of EMT target genes. PTEN (phosphatase and tensin homologue deleted from chromosome 10) is known to...

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Source

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Identifiers

PMID: 24278390
DOI: 10.1371/journal.pone.0081133
PMCID: PMC3838341

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Involvement of TGFβ-induced phosphorylation of the PTEN C-terminus on TGFβ-induced acquisition of malignant phenotypes in lung cancer cells.PMID 24278390Read ↗

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