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Article

Suppression of Akt1-β-catenin pathway in advanced prostate cancer promotes TGFβ1-mediated epithelial to mesenchymal transition and metastasis.

Cancer letters - 28 Aug 2017

Gao Fei, Alwhaibi Abdulrahman, Sabbineni Harika, Verma Arti, Eldahshan Wael, Somanath Payaningal R

Abstract excerpt

Akt1 is essential for the oncogenic transformation and tumor growth in various cancers. However, the precise role of Akt1 in advanced cancers is conflicting. Using a neuroendocrine TRansgenic Adenocarcinoma of the Mouse Prostate (TRAMP) model, we first show that the genetic ablation or pharmacological inhibition of Akt1 in mice blunts oncogenic transformation and prostate cancer (PCa) growth. Intriguingly,...

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Identifiers

PMID: 28602980
DOI: 10.1016/j.canlet.2017.05.028
PMCID: PMC5538588

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