Article
Transforming growth factor-β1 induces epithelial-to-mesenchymal transition in human lung cancer cells via PI3K/Akt and MEK/Erk1/2 signaling pathways.
Molecular biology reports - 1 Apr 2012
Chen Xiao-Feng, Zhang Hui-Jun, Wang Hai-Bing, Zhu Jun, Zhou Wen-Yong, Zhang Hui, Zhao Ming-Chuan, Su Jin-Mei, Gao Wen, Zhang Lei, Fei Ke, Zhang Hong-Tao, Wang He-Yong
Abstract excerpt
Metastasis of tumor cells is associated with epithelial-to-mesenchymal transition (EMT), which is a process whereby epithelial cells lose their polarity and acquire new features of mesenchyme. EMT has been reported to be induced by transforming growth factor-β1 (TGF-β1), but its mechanism remains elusive. In this study, we performed a study to investigate whether PI3K/Akt and MAPK/Erk1/2 signaling pathways...
Topics
- Biomarkers, Tumor
- Cadherins
- Cell Line, Tumor
- Cell Movement
- Cell Shape
- Epithelial-Mesenchymal Transition
- Fibronectins
- Humans
- Lung Neoplasms
- MAP Kinase Signaling System