Article
Genetic variation in SULF2 is associated with postprandial clearance of triglyceride-rich remnant particles and triglyceride levels in healthy subjects.
PloS one - 1 Jan 2013
Matikainen Niina, Burza Maria Antonella, Romeo Stefano, Hakkarainen Antti, Adiels Martin, Folkersen Lasse, Eriksson Per, Lundbom Nina, Ehrenborg Ewa, Orho-Melander Marju, Taskinen Marja-Riitta, Borén Jan
Abstract excerpt
CONTEXT: Nonfasting (postprandial) triglyceride concentrations have emerged as a clinically significant cardiovascular disease risk factor that results from accumulation of remnant triglyceride-rich lipoproteins (TRLs) in the circulation. The remnant TRLs are cleared from the circulation by hepatic uptake, but the specific mechanisms involved are unclear. The syndecan-1 heparan sulfate proteoglycan (HSPG) pathway...
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