Article
SULF2 strongly prediposes to fasting and postprandial triglycerides in patients with obesity and type 2 diabetes mellitus.
Obesity (Silver Spring, Md.) - 1 May 2014
Hassing H Carlijne, Surendran R Preethi, Derudas Bruno, Verrijken An, Francque Sven M, Mooij Hans L, Bernelot Moens Sophie J, Hart Leen M 't, Nijpels Giel, Dekker Jacqueline M, Williams Kevin Jon, Stroes Erik S G, Van Gaal Luc F, Staels Bart, Nieuwdorp Max, Dallinga-Thie Geesje M
Abstract excerpt
OBJECTIVE: Hepatic overexpression of sulfatase-2 (SULF2), a heparan sulfate remodeling enzyme, strongly contributes to high triglyceride (TG) levels in obese, type 2 diabetic (T2DM) db/db mice. Nevertheless, data in humans are lacking. Here, the association of human hepatic SULF2 expression and SULF2 gene variants with TG metabolism in patients with obesity and/or T2DM was investigated. METHODS: Liver biopsies...
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