Article
Ext1 heterozygosity causes a modest effect on postprandial lipid clearance in humans.
Journal of lipid research - 1 Mar 2015
Mooij Hans L, Bernelot Moens Sophie J, Gordts PhilipL S M, Stanford KristinI, Foley ErinM, van den Boogert MarjoleinA W, Witjes JuliaJ, Hassing H Carlijne, Tanck MichaelW, van de Sande MichielA J, Levels J Han, Kastelein JohnJ P, Stroes ErikS G, Dallinga-Thie GeesjeM, Esko JeffD, Nieuwdorp Max
Abstract excerpt
Elevated nonfasting TG-rich lipoprotein levels are a risk factor for CVD. To further evaluate the relevance of LDL-receptor (LDLr) pathway and heparan sulfate proteoglycans (HSPGs) in TG homeostasis, we analyzed fasting and postprandial TG levels in mice bearing combined heterozygous mutations in both Exostosin (Ext) 1 and Ldlr, in subjects with hereditary multiple exostosis (HME) due to a heterozygous...
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