Article
Fine-mapping the genetic association of the major histocompatibility complex in multiple sclerosis: HLA and non-HLA effects.
PLoS genetics - 1 Nov 2013
Patsopoulos Nikolaos A, Barcellos Lisa F, Hintzen Rogier Q, Schaefer Catherine, van Duijn Cornelia M, Noble Janelle A, Raj Towfique, Gourraud Pierre-Antoine, Stranger Barbara E, Oksenberg Jorge, Olsson Tomas, Taylor Bruce V, Sawcer Stephen, Hafler David A, Carrington Mary, De Jager Philip L, de Bakker Paul I W
Abstract excerpt
The major histocompatibility complex (MHC) region is strongly associated with multiple sclerosis (MS) susceptibility. HLA-DRB1*15:01 has the strongest effect, and several other alleles have been reported at different levels of validation. Using SNP data from genome-wide studies, we imputed and tested classical alleles and amino acid polymorphisms in 8 classical human leukocyte antigen (HLA) genes in 5,091 cases...
Topics
- Alleles
- Chromosome Mapping
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- HLA-DP beta-Chains
- HLA-DRB1 Chains
- Haplotypes
- Histocompatibility Antigens Class I