Article
LSD1/KDM1A promotes hematopoietic commitment of hemangioblasts through downregulation of Etv2.
Proceedings of the National Academy of Sciences of the United States of America - 10 Nov 2015
Takeuchi Miki, Fuse Yuji, Watanabe Mana, Andrea Christina-Sylvia, Takeuchi Miho, Nakajima Hitomi, Ohashi Ken, Kaneko Hiroshi, Kobayashi-Osaki Maki, Yamamoto Masayuki, Kobayashi Makoto
Abstract excerpt
The hemangioblast is a progenitor cell with the capacity to give rise to both hematopoietic and endothelial progenitors. Currently, the regulatory mechanisms underlying hemangioblast formation are being elucidated, whereas those controllers for the selection of hematopoietic or endothelial fates still remain a mystery. To answer these questions, we screened for zebrafish mutants that have defects in the...
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