Article

Hematopoietic stem and progenitor cell heterogeneity is inherited from the embryonic hemogenic endothelium

2022-09-30

Abstract excerpt

Multipotent hematopoietic stem/progenitor cells (HSPCs) generate all mature blood cells in the erythroid, lymphoid, and myeloid lineages. HSPCs are initially produced in the embryo, via transdifferentiation of hemogenic endothelial cells (hemECs) in the aorta-gonad mesonephros (AGM). HSPCs in the AGM are functionally heterogenous in differentiation and proliferative output, but how these intrinsic differences are...

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Literature Corpus work: e99eccd4-62e2-55af-b4f2-6e991b329bce
DOI: 10.1101/2022.09.28.509963

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