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Article

Genetic prediction of quantitative lipid traits: comparing shrinkage models to gene scores.

Genetic epidemiology - 1 Jan 2014

Warren Helen, Casas Juan-Pablo, Hingorani Aroon, Dudbridge Frank, Whittaker John

Abstract excerpt

Accurate genetic prediction of quantitative traits related to complex disease risk would have potential clinical impact, so investigation of statistical methodology to improve predictive performance is important. We compare a simple approach of polygenic scores using top ranking single nucleotide polymorphisms (SNPs) to a set of shrinkage models, namely Ridge Regression, Lasso and Hyper-Lasso. These penalised...

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PMID: 24272946
DOI: 10.1002/gepi.21777

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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