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Article

Improved genetic prediction of complex traits from individual-level data or summary statistics.

Nature communications - 7 Jul 2021

Zhang Qianqian, Privé Florian, Vilhjálmsson Bjarni, Speed Doug

Abstract excerpt

Most existing tools for constructing genetic prediction models begin with the assumption that all genetic variants contribute equally towards the phenotype. However, this represents a suboptimal model for how heritability is distributed across the genome. Therefore, we develop prediction tools that allow the user to specify the heritability model. We compare individual-level data prediction tools using 14 UK...

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PMID: 34234142
DOI: 10.1038/s41467-021-24485-y
PMCID: PMC8263809

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