Article
Polygenic Risk Score for Low-Density Lipoprotein Cholesterol Is Associated With Risk of Ischemic Heart Disease and Enriches for Individuals With Familial Hypercholesterolemia.
Circulation. Genomic and precision medicine - 1 Feb 2021
Wu Haoyu, Forgetta Vincenzo, Zhou Sirui, Bhatnagar Sahir R, Paré Guillaume, Richards J Brent
Abstract excerpt
BACKGROUND: The clinical implications of a polygenic risk score (PRS) for LDL-C (low-density lipoprotein cholesterol) are not well understood, both within the general population and individuals with familial hypercholesterolemia (FH). METHODS: We developed the LDL-C PRS using Least Absolute Shrinkage and Selection Operator regression in 377 286 White British participants from UK Biobank and tested its association...
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