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Article

Leptin deficiency impairs maturation of dendritic cells and enhances induction of regulatory T and Th17 cells.

European journal of immunology - 1 Mar 2014

Moraes-Vieira Pedro M M, Larocca Rafael A, Bassi Enio J, Peron Jean Pierre S, Andrade-Oliveira Vinícius, Wasinski Frederick, Araujo Ronaldo, Thornley Thomas, Quintana Francisco J, Basso Alexandre S, Strom Terry B, Câmara Niels O S

Abstract excerpt

Leptin is an adipose-secreted hormone that plays an important role in both metabolism and immunity. Leptin has been shown to induce Th1-cell polarization and inhibit Th2-cell responses. Additionally, leptin induces Th17-cell responses, inhibits regulatory T (Treg) cells and modulates autoimmune diseases. Here, we investigated whether leptin mediates its activity on T cells by influencing dendritic cells (DCs) to...

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Identifiers

PMID: 24271843
DOI: 10.1002/eji.201343592
PMCID: PMC4973395

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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