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Article

Inhibiting STAT5 by the BET bromodomain inhibitor JQ1 disrupts human dendritic cell maturation.

Journal of immunology (Baltimore, Md. : 1950) - 1 Apr 2015

Toniolo Patricia A, Liu Suhu, Yeh Jennifer E, Moraes-Vieira Pedro M, Walker Sarah R, Vafaizadeh Vida, Barbuto José Alexandre M, Frank David A

Abstract excerpt

Maturation of dendritic cells (DCs) is required to induce T cell immunity, whereas immature DCs can induce immune tolerance. Although the transcription factor STAT5 is suggested to participate in DC maturation, its role in this process remains unclear. In this study, we investigated the effect of STAT5 inhibition on LPS-induced maturation of human monocyte-derived DCs (Mo-DCs). We inhibited STAT5 by treating...

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Identifiers

PMID: 25725100
DOI: 10.4049/jimmunol.1401635
PMCID: PMC4369449

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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