Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Sirt6 regulates dendritic cell differentiation, maturation, and function.

Aging - 1 Jan 2016

Lasigliè Denise, Boero Silvia, Bauer Inga, Morando Sara, Damonte Patrizia, Cea Michele, Monacelli Fiammetta, Odetti Patrizio, Ballestrero Alberto, Uccelli Antonio, Mostoslavsky Raul, Poggi Alessandro, Nencioni Alessio

Abstract excerpt

Dendritic cells (DCs) are antigen-presenting cells that critically influence decisions about immune activation or tolerance. Impaired DC function is at the core of common chronic disorders and contributes to reduce immunocompetence during aging. Knowledge on the mechanisms regulating DC generation and function is necessary to understand the immune system and to prevent disease and immunosenescence. Here we show...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Dendritic Cells
Share to Histocompatibility Antigens Class II

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Histone Deacetylase Inhibitors

Share to Interleukin-12

Share to Mice, 129 Strain

Share to Receptors, CCR7

Share to Sirtuins

Share to Toll-Like Receptors

Source

Open in PubMed Open full text

Identifiers

PMID: 26761436
DOI: 10.18632/aging.100870
PMCID: PMC4761712

Genes

CCR7
SIRT6
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Sirt6 regulates dendritic cell differentiation, maturation, and function.PMID 26761436Read ↗

Dendritic cells as gatekeepers of tolerance.Semantic proximity Read ↗

Nuclear Sirtuins and the Aging of the Immune SystemSemantic proximity Read ↗

Transcriptional Networks Driving Dendritic Cell Differentiation and Function.Semantic proximity Read ↗

Progression of Chronic Liver Inflammation and Fibrosis Driven by Activation of c-JUN Signaling in Sirt6 Mutant MiceSemantic proximity Read ↗

Sirtuin 6 inhibits group 3 innate lymphoid cell function and gut immunity by suppressing IL-22 productionSemantic proximity Read ↗

Dendritic Cells: Master Regulators of the Immune ResponseSemantic proximity Read ↗

Sirtuin 1 regulates the phenotype and functions of dendritic cells through Ido1 pathway in obesity.Semantic proximity Read ↗

The ontogenetic path of human dendritic cells.Semantic proximity Read ↗

Myeloid dendritic cells: Development, functions, and role in atherosclerotic inflammation.Semantic proximity Read ↗

Human dendritic cell subsets: an update.Semantic proximity Read ↗

LPS activation is required for migratory activity and antigen presentation by tolerogenic dendritic cells.Semantic proximity Read ↗

Umbilical cord-derived mesenchymal stem cells instruct dendritic cells to acquire tolerogenic phenotypes through the IL-6-mediated upregulation of SOCS1.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.