Article
Wnt5a skews dendritic cell differentiation to an unconventional phenotype with tolerogenic features.
Journal of immunology (Baltimore, Md. : 1950) - 15 Oct 2011
Valencia Jaris, Hernández-López Carmen, Martínez Víctor G, Hidalgo Laura, Zapata Agustín G, Vicente Ángeles, Varas Alberto, Sacedón Rosa
Abstract excerpt
Dendritic cells (DCs) are critical regulators of immune responses that integrate signals from the innate and adaptive immune system and orchestrate T cell responses toward either immunity or tolerance. Growing evidence points to the Wnt signaling pathway as a pivotal piece in the immune balance and focuses on DCs as a direct target for their immunoregulatory role. Our results show that the increase in Wnt5a...
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