Coexpression networks implicate human midfetal deep cortical projection neurons in the pathogenesis of autism.

doi:10.1016/j.cell.2013.10.020

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Article

Coexpression networks implicate human midfetal deep cortical projection neurons in the pathogenesis of autism.

Cell - 21 Nov 2013

Willsey A Jeremy, Sanders Stephan J, Li Mingfeng, Dong Shan, Tebbenkamp Andrew T, Muhle Rebecca A, Reilly Steven K, Lin Leon, Fertuzinhos Sofia, Miller Jeremy A, Murtha Michael T, Bichsel Candace, Niu Wei, Cotney Justin, Ercan-Sencicek A Gulhan, Gockley Jake, Gupta Abha R, Han Wenqi, He Xin, Hoffman Ellen J, Klei Lambertus, Lei Jing, Liu Wenzhong, Liu Li, Lu Cong, Xu Xuming, Zhu Ying, Mane Shrikant M, Lein Ed S, Wei Liping, Noonan James P, Roeder Kathryn, Devlin Bernie, Sestan Nenad, State Matthew W

Abstract excerpt

Autism spectrum disorder (ASD) is a complex developmental syndrome of unknown etiology. Recent studies employing exome- and genome-wide sequencing have identified nine high-confidence ASD (hcASD) genes. Working from the hypothesis that ASD-associated mutations in these biologically pleiotropic genes will disrupt intersecting developmental processes to contribute to a common phenotype, we have attempted to...

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PMID: 24267886
DOI: 10.1016/j.cell.2013.10.020
PMCID: PMC3995413

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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