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Article

Genome-wide prediction and functional characterization of the genetic basis of autism spectrum disorder.

Nature neuroscience - 1 Nov 2016

Krishnan Arjun, Zhang Ran, Yao Victoria, Theesfeld Chandra L, Wong Aaron K, Tadych Alicja, Volfovsky Natalia, Packer Alan, Lash Alex, Troyanskaya Olga G

Abstract excerpt

Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder with a strong genetic basis. Yet, only a small fraction of potentially causal genes-about 65 genes out of an estimated several hundred-are known with strong genetic evidence from sequencing studies. We developed a complementary machine-learning approach based on a human brain-specific gene network to present a genome-wide prediction of autism...

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Identifiers

PMID: 27479844
DOI: 10.1038/nn.4353
PMCID: PMC5803797

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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