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Article

Functional analysis of a breast cancer-associated FGFR2 single nucleotide polymorphism using zinc finger mediated genome editing.

PloS one - 1 Jan 2013

Robbez-Masson Luisa J, Bödör Csaba, Jones J Louise, Hurst Helen C, Fitzgibbon Jude, Hart Ian R, Grose Richard P

Abstract excerpt

Genome wide association studies have identified single nucleotide polymorphisms (SNP) within fibroblast growth factor receptor 2 (FGFR2) as one of the highest ranking risk alleles in terms of development of breast cancer. The potential effect of these SNPs, in intron two, was postulated to be due to the differential binding of cis-regulatory elements, such as transcription factors, since all the SNPs in linkage...

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Identifiers

PMID: 24265722
DOI: 10.1371/journal.pone.0078839
PMCID: PMC3827080

Genes

FGFR2
FOXA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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