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Article

Master regulators of FGFR2 signalling and breast cancer risk.

Nature communications - 1 Jan 2013

Fletcher Michael N C, Castro Mauro A A, Wang Xin, de Santiago Ines, O'Reilly Martin, Chin Suet-Feung, Rueda Oscar M, Caldas Carlos, Ponder Bruce A J, Markowetz Florian, Meyer Kerstin B

Abstract excerpt

The fibroblast growth factor receptor 2 (FGFR2) locus has been consistently identified as a breast cancer risk locus in independent genome-wide association studies. However, the molecular mechanisms underlying FGFR2-mediated risk are still unknown. Using model systems we show that FGFR2-regulated genes are preferentially linked to breast cancer risk loci in expression quantitative trait loci analysis, supporting...

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Source

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Identifiers

PMID: 24043118
DOI: 10.1038/ncomms3464
PMCID: PMC3778544

Genes

FGFR2
FOXA1
GATA3
PTTG1
SPDEF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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