Article
FGFR2 variants and breast cancer risk: fine-scale mapping using African American studies and analysis of chromatin conformation.
Human molecular genetics - 1 May 2009
Udler Miriam S, Meyer Kerstin B, Pooley Karen A, Karlins Eric, Struewing Jeffery P, Zhang Jinghui, Doody David R, MacArthur Stewart, Tyrer Jonathan, Pharoah Paul D, Luben Robert, Bernstein Leslie, Kolonel Laurence N, Henderson Brian E, Le Marchand Loic, Ursin Giske, Press Michael F, Brennan Paul, Sangrajrang Suleeporn, Gaborieau Valerie, Odefrey Fabrice, Shen Chen-Yang, Wu Pei-Ei, Wang Hui-Chun, Kang Daehee, Yoo Keun-Young, Noh Dong-Young, Ahn Sei-Hyun, Ponder Bruce A J, Haiman Christopher A, Malone Kathleen E, Dunning Alison M, Ostrander Elaine A, Easton Douglas F
Abstract excerpt
Genome-wide association studies have identified FGFR2 as a breast cancer (BC) susceptibility gene in populations of European and Asian descent, but a causative variant has not yet been conclusively identified. We hypothesized that the weaker linkage disequilibrium across this associated region in populations of African ancestry might help refine the set of candidate-causal single nucleotide polymorphisms (SNPs)...
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