Article
Allele-specific regulation of FGFR2 expression is cell type-dependent and may increase breast cancer risk through a paracrine stimulus involving FGF10.
Breast cancer research : BCR - 18 Jul 2011
Huijts Petra E A, van Dongen Minka, de Goeij Moniek C M, van Moolenbroek Adrian J, Blanken Freek, Vreeswijk Maaike P G, de Kruijf Esther M, Mesker Wilma E, van Zwet Erik W, Tollenaar Rob A E M, Smit Vincent T H B M, van Asperen Christi J, Devilee Peter
Abstract excerpt
INTRODUCTION: SNPs rs2981582 and rs2981578, located in a linkage disequilibrium block (LD block) within intron 2 of the fibroblast growth factor receptor 2 gene (FGFR2), are associated with a mildly increased breast cancer risk. Allele-specific regulation of FGFR2 mRNA expression has been reported previously, but the molecular basis for the association of these variants with breast cancer has remained elusive to...
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