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Article

Allele-specific up-regulation of FGFR2 increases susceptibility to breast cancer.

PLoS biology - 6 May 2008

Meyer Kerstin B, Maia Ana-Teresa, O'Reilly Martin, Teschendorff Andrew E, Chin Suet-Feung, Caldas Carlos, Ponder Bruce A J

Abstract excerpt

The recent whole-genome scan for breast cancer has revealed the FGFR2 (fibroblast growth factor receptor 2) gene as a locus associated with a small, but highly significant, increase in the risk of developing breast cancer. Using fine-scale genetic mapping of the region, it has been possible to na...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18462018
DOI: 10.1371/journal.pbio.0060108
PMCID: PMC2365982

Genes

FGFR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18462018-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Allele-specific up-regulation of FGFR2 increases susceptibility to breast cancer.PMID 18462018Read ↗

Fine-scale mapping of the FGFR2 breast cancer risk locus: putative functional variants differentially bind FOXA1 and E2F1.Semantic proximity Read ↗

FGFR2 variants and breast cancer risk: fine-scale mapping using African American studies and analysis of chromatin conformation.Semantic proximity Read ↗

FGFR2 risk SNPs confer breast cancer risk by augmenting oestrogen responsiveness.Semantic proximity Read ↗

Genetic variants in fibroblast growth factor receptor 2 (FGFR2) contribute to susceptibility of breast cancer in Chinese women.Semantic proximity Read ↗

Allele-specific regulation of FGFR2 expression is cell type-dependent and may increase breast cancer risk through a paracrine stimulus involving FGF10.Semantic proximity Read ↗

A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer.Semantic proximity Read ↗

Assessing interactions between the associations of fibroblast growth factor receptor 2 common genetic variants and hormone receptor status with breast cancer risk.Semantic proximity Read ↗

Functional analysis of a breast cancer-associated FGFR2 single nucleotide polymorphism using zinc finger mediated genome editing.Semantic proximity Read ↗

Genetic and epigenetic mechanisms down-regulate FGF receptor 2 to induce melanoma-associated antigen A in breast cancer.Semantic proximity Read ↗

Fine-mapping identifies two additional breast cancer susceptibility loci at 9q31.2.Semantic proximity Read ↗

Variants of FGFR2 and their associations with breast cancer risk: a HUGE systematic review and meta-analysis.Semantic proximity Read ↗

FGFR2 intronic SNPs and breast cancer risk: associations with tumor characteristics and interactions with exogenous exposures and other known breast cancer risk factors.Semantic proximity Read ↗

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