Article
Variation in the FGFR2 gene and the effects of postmenopausal hormone therapy on invasive breast cancer.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Nov 2009
Prentice Ross L, Huang Ying, Hinds David A, Peters Ulrike, Pettinger Mary, Cox David R, Beilharz Erica, Chlebowski Rowan T, Rossouw Jacques E, Caan Bette, Ballinger Dennis G
Abstract excerpt
BACKGROUND: Breast cancer concern is a major reason for the recent marked reduction in use of postmenopausal hormone therapy, although equally effective means of controlling menopausal symptoms are lacking. Single nucleotide polymorphisms (SNP) in the fibroblast growth factor receptor 2 (FGFR2) gene are substantially associated with postmenopausal breast cancer risk and could influence hormone therapy effects....
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