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Article

FGFR2 risk SNPs confer breast cancer risk by augmenting oestrogen responsiveness.

Carcinogenesis - 1 Aug 2016

Campbell Thomas M, Castro Mauro A A, de Santiago Ines, Fletcher Michael N C, Halim Silvia, Prathalingam Radhika, Ponder Bruce A J, Meyer Kerstin B

Abstract excerpt

The fibroblast growth factor receptor 2 (FGFR2) locus is consistently the top hit in genome-wide association studies for oestrogen receptor-positive (ER(+)) breast cancer. Yet, its mode of action continues to be controversial. Here, we employ a systems biology approach to demonstrate that signalling via FGFR2 counteracts cell activation by oestrogen. In the presence of oestrogen, the oestrogen receptor (ESR1)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27236187
DOI: 10.1093/carcin/bgw065
PMCID: PMC4967216

Genes

FGFR2
ESR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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