Article
Chloroquine resistance transporter drives divergent multi-locus drug resistance genetic backgrounds and susceptibility in Gambian Plasmodium falciparum.
Journal of global antimicrobial resistance - 1 Jun 2026
Drammeh Ndey Fatou, Bojang Fatoumata, Nganyewo Nora Nghochuzie, Jawara Aminata Seedy, Manneh Baboucarr, Correa Simon, Amambua-Ngwa Brandon Nji, Mbye Haddijatou, Oriero Eniyou Cheryll, Sutherland Colin J, D'Alessandro Umberto, Amambua-Ngwa Alfred
Abstract excerpt
OBJECTIVE: Sustained antimalarial drug use against Plasmodium falciparum has often resulted in drug resistance and the selection of associated genetic markers in malaria endemic populations. The genetic markers of resistance to legacy drugs like chloroquine persist in The Gambia. This study asses...
Topics
- Plasmodium falciparum
- Drug Resistance
- Antimalarials
- Membrane Transport Proteins
- Protozoan Proteins
- Gambia
- Humans
- Chloroquine
- Malaria, Falciparum
- Inhibitory Concentration 50
- Haplotypes
- Genotype
- Parasitic Sensitivity Tests