Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Chloroquine resistance transporter drives divergent multi-locus drug resistance genetic backgrounds and susceptibility in Gambian Plasmodium falciparum.

Journal of global antimicrobial resistance - 1 Jun 2026

Drammeh Ndey Fatou, Bojang Fatoumata, Nganyewo Nora Nghochuzie, Jawara Aminata Seedy, Manneh Baboucarr, Correa Simon, Amambua-Ngwa Brandon Nji, Mbye Haddijatou, Oriero Eniyou Cheryll, Sutherland Colin J, D'Alessandro Umberto, Amambua-Ngwa Alfred

Abstract excerpt

OBJECTIVE: Sustained antimalarial drug use against Plasmodium falciparum has often resulted in drug resistance and the selection of associated genetic markers in malaria endemic populations. The genetic markers of resistance to legacy drugs like chloroquine persist in The Gambia. This study assesses the effect of these legacy drug-resistance genomic backgrounds on in vitro responses to antimalarial drugs in The...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antimalarials
Share to Drug Resistance

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genotype

Share to Haplotypes

Share to Malaria, Falciparum

Share to Membrane Transport Proteins

Share to Plasmodium falciparum

Share to Protozoan Proteins

Source

Identifiers

PMID: 41985582
DOI: 10.1016/j.jgar.2026.04.003

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Chloroquine resistance transporter drives divergent multi-locus drug resistance genetic backgrounds and susceptibility in Gambian Plasmodium falciparum.PMID 41985582Read ↗

Sustained Ex Vivo Susceptibility of Plasmodium falciparum to Artemisinin Derivatives but Increasing Tolerance to Artemisinin Combination Therapy Partner Quinolines in The Gambia.Semantic proximity Read ↗

Molecular Surveillance of malaria in Nigeria reveals expansion of chloroquine-sensitive infectionsSemantic proximity Read ↗

Prevalence of mutations in the Plasmodium falciparum chloroquine resistance transporter, PfCRT, and association with ex vivo susceptibility to common anti-malarial drugs against African Plasmodium falciparum isolates.Semantic proximity Read ↗

Changes in malaria parasite drug resistance in an endemic population over a 25-year period with resulting genomic evidence of selection.Semantic proximity Read ↗

Genetic diversity and evolutionary perspectives of Pfcrt in Plasmodium falciparum: insights from Indian and global isolates.Semantic proximity Read ↗

Frequency distribution of antimalarial drug-resistant alleles among isolates of Plasmodium falciparum in Bangui, Central African Republic.Semantic proximity Read ↗

Chloroquine resistant P. falciparum prevalence is low and unchanged between 1990 and 2005 in Guinea-Bissau: an effect of high chloroquine dosage?Semantic proximity Read ↗

Prevalence of Plasmodium falciparum antimalarial drug resistance genes in Southeastern Gabon from 2011 to 2014Semantic proximity Read ↗

Temporal trends in prevalence of Plasmodium falciparum drug resistance alleles over two decades of changing antimalarial policy in coastal KenyaSemantic proximity Read ↗

Molecular Epidemiology of Drug Resistance Genes in Plasmodium falciparum Isolates Imported from Nigeria between 2016 and 2020: Continued Emergence of Fully Resistant Pfdhfr-Pfdhps Alleles.Semantic proximity Read ↗

PfCRT and its role in antimalarial drug resistance.Semantic proximity Read ↗

Distribution and Temporal Dynamics of Plasmodium falciparum Chloroquine Resistance Transporter Mutations Associated With Piperaquine Resistance in Northern Cambodia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.