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Article

Consistent signatures of selection from genomic analysis of pairs of temporal and spatial Plasmodium falciparum populations from The Gambia.

Scientific reports - 26 Jun 2018

Amambua-Ngwa Alfred, Jeffries David, Amato Roberto, Worwui Archibald, Karim Mane, Ceesay Sukai, Nyang Haddy, Nwakanma Davis, Okebe Joseph, Kwiatkowski Dominic, Conway David J, D'Alessandro Umberto

Abstract excerpt

Genome sequences of 247 Plasmodium falciparum isolates collected in The Gambia in 2008 and 2014 were analysed to identify changes possibly related to the scale-up of antimalarial interventions that occurred during this period. Overall, there were 15 regions across the genomes with signatures of positive selection. Five of these were sweeps around known drug resistance and antigenic loci. Signatures at antigenic...

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Identifiers

PMID: 29946063
DOI: 10.1038/s41598-018-28017-5
PMCID: PMC6018809

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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