Article
A genome wide association study of Plasmodium falciparum susceptibility to 22 antimalarial drugs in Kenya.
PloS one - 1 Jan 2014
Wendler Jason P, Okombo John, Amato Roberto, Miotto Olivo, Kiara Steven M, Mwai Leah, Pole Lewa, O'Brien John, Manske Magnus, Alcock Dan, Drury Eleanor, Sanders Mandy, Oyola Samuel O, Malangone Cinzia, Jyothi Dushyanth, Miles Alistair, Rockett Kirk A, MacInnis Bronwyn L, Marsh Kevin, Bejon Philip, Nzila Alexis, Kwiatkowski Dominic P
Abstract excerpt
BACKGROUND: Drug resistance remains a chief concern for malaria control. In order to determine the genetic markers of drug resistant parasites, we tested the genome-wide associations (GWA) of sequence-based genotypes from 35 Kenyan P. falciparum parasites with the activities of 22 antimalarial drugs. METHODS AND PRINCIPAL FINDINGS: Parasites isolated from children with acute febrile malaria were adapted to...
Topics
- Antimalarials
- Child
- DNA, Protozoan
- Drug Resistance
- Genome-Wide Association Study
- Humans
- Kenya
- Malaria, Falciparum
- Plasmodium falciparum