Article
Two decades of molecular surveillance in Senegal reveal rapid changes in known drug resistance mutations over time.
Malaria journal - 9 Jul 2024
Ndiaye Yaye D, Wong Wesley, Thwing Julie, Schaffner Stephen F, Brenneman Katelyn Vendrely, Tine Abdoulaye, Diallo Mamadou A, Deme Awa B, Sy Mouhamad, Bei Amy K, Thiaw Alphonse B, Daniels Rachel, Ndiaye Tolla, Gaye Amy, Ndiaye Ibrahima M, Toure Mariama, Gadiaga Nogaye, Sene Aita, Sow Djiby, Garba Mamane N, Yade Mamadou S, Dieye Baba, Diongue Khadim, Zoumarou Daba, Ndiaye Aliou, Gomis Jules F, Fall Fatou B, Ndiop Medoune, Diallo Ibrahima, Sene Doudou, Macinnis Bronwyn, Seck Mame C, Ndiaye Mouhamadou, Ngom Bassirou, Diedhiou Younouss, Mbaye Amadou M, Ndiaye Lamine, Sy Ngayo, Badiane Aida S, Hartl Daniel L, Wirth Dyann F, Volkman Sarah K, Ndiaye Daouda
Abstract excerpt
BACKGROUND: Drug resistance in Plasmodium falciparum is a major threat to malaria control efforts. Pathogen genomic surveillance could be invaluable for monitoring current and emerging parasite drug resistance. METHODS: Data from two decades (2000-2020) of continuous molecular surveillance of P. falciparum parasites from Senegal were retrospectively examined to assess historical changes in malaria drug resistance...
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