Article
Diversity of the MBL2 gene in various Brazilian populations and the case of selection at the mannose-binding lectin locus.
Human immunology - 1 Sept 2006
Boldt A B W, Culpi L, Tsuneto L T, de Souza I R, Kun J F J, Petzl-Erler M L
Abstract excerpt
The mannose binding lectin (MBL2) polymorphism is responsible for a common immunodeficiency in the human species. There were suggestions that the MBL2 polymorphism has been under balancing selection, based on the high global frequency of alleles generating MBL deficiency and on the worldwide distribution of diseases negatively associated with them. To describe the distribution of MBL2 allelic haplotypes in...
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