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Article

Association of a new mannose-binding lectin variant with severe malaria in Gabonese children.

Genes and immunity - 1 Jul 2006

Boldt A B W, Luty A, Grobusch M P, Dietz K, Dzeing A, Kombila M, Kremsner P G, Kun J F J

Abstract excerpt

Mannose-binding lectin (MBL2) variants that decrease the plasma level of the protein or encode dysfunctional proteins are frequently associated with the severity of a number of infections and autoimmune disorders. The high frequencies of these variants in most populations of the world are probably maintained by some selective advantage against widespread diseases. We found 14 new MBL2 allelic haplotypes, two of...

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Source

Identifiers

PMID: 16738667
DOI: 10.1038/sj.gene.6364312

Genes

MBL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Association of a new mannose-binding lectin variant with severe malaria in Gabonese children.PMID 16738667Read ↗

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An analysis of genetic variation across the MBL2 locus in Dutch Caucasians indicates that 3' haplotypes could modify circulating levels of mannose-binding lectin.Semantic proximity Read ↗

Mannose-binding lectin and its genetic variants.Semantic proximity Read ↗

Sequence analysis of the mannose-binding lectin (MBL2) gene reveals a high degree of heterozygosity with evidence of selection.Semantic proximity Read ↗

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